Thomas W. Clarkson, in Handbook of Pesticide Toxicology (Second Edition), 2001. Antimony potassium tartrate có công thức là K 2 Sb 2 (C 4 H 2 O 6) 2 hoặc C 8 H 10 K 2 O 15 Sb 2. Antimonials have poor oral absorption and are therefore administered by the parenteral route. 3 H 2 O . Her gastrointestinal conditions normalized over about 2 weeks. Each dose should be given 2 hr after a light meal and the patient should remain recumbent for 1 hr after treatment (AMA, 1977). The recent mapping of the schistosoma mansoni genome, which showed that it has seven pairs of autosomal chromosomes and one pair of sex chromosomes, might help in developing new drugs and methods of treatment for schistosomiasis. During baking a cake after an old recipe tatar cream was by mistake exchanged with tatar emetic, about 6 g were used. It has been used for treating a number of tropical diseases, and it still is the drug of choice for treating infection by Schistosoma japonicum. (NTP, 1992). It has irritant emetic properties and may cause lethal cardiac toxicity among other adverse effects. He had been drinking in the night. It is more effective in eliminating N. americanus than Ancyl. Three patients were discharged on day 12 in good health and had normal clinical results and no adverse indications at 1 month follow-up. Long-term peroral exposure to high doses of antimony may also induce signs of liver toxicity. This has led to its use also in control of schistosomiasis using mass chemotherapy. Further information. ANTIMONATE(1-), AQUA[TARTRATO(4-)]-, POTASSIUM, SESQUIHYDRATE, DIMER, ANTIMONATE(1-), OXO(TARTRATO)-, POTASSIUM SESQUIHYDRATE, DIMER, ANTIMONATE(2)-, BIS(MU-TARTRATO(4-))DI-, DIPOTASSIUM, TRIHYDRATE, ANTIMONATE(2-), BIS[MU-TARTRATO(4-)]DI-, DIPOTASSIUM, TRIHYDRATE, ANTIMONATE(2-), BIS[MU-[2,3-DIHYDROXYBUTANEDIOATO(4-)-O1,O2:O3,O4]]DI-, DIPOTASSIUM, TRIHYDRATE, STEREOISOMER, ANTIMONYL POTASSIUM TARTRATE, SESQUIHYDRATE, BUTANEDIOIC ACID, 2,3-DIHYDROXY- [R-(R*,R*)]-, ANTIMONY COMPLEX. In Europe, i.v. vitamins, herbal supplements, etc. Trivalent antimony compounds are more toxic than the pentavalent because they are excreted slowly., Gastrointestinal disturbance, Headache, Dizziness, Weakness, Kidney injury may occur. These therapeutic doses may be compared with 5 mg/person/day, the rate of respiratory intake of antimony considered safe for workers exposed to various antimony compounds. antimony potassium tartrate nedir ve antimony potassium tartrate ne demek sorularına hızlı cevap veren sözlük sayfası. Two patients given a high i.v. The doses of antimony potassium tartrate received from cough medicines generally cause no side effects. Similarly for treating S. mattheei infection in sheep and cattle, stibophen has been given at a dose of 5-10 mg/kg, intramuscularly for 3-10 days [70,71]. "c" indicates that although not listed by name and CAS number, this chemical is reportable under one or more of the EPCRA section 313 chemical categories. In fact, the resemblance is so close that a distinction may be impossible unless the cause is known as the result of history or chemical analysis. Antimony potassium tartrate (APT) at doses up to 168 mg ATP (or 30.63 mg antimony)/kg body weight (bw)/day (mg/kg/day) was administered in drinking water to juvenile male and female rats continuously for 14 days, followed by 1 day of observation . Praziquantel has little or no effect on schistosoma eggs or immature worms. Antimony potassium tartrate, also known as potassium antimony tartrate, potassium antimontarterate, formula K2Sb2 (C4H2O6)2 and is the double salt of potassium and antimony of tartaric acid. It is safe for treatment in pregnancy, lactation, and in young children. All of these drugs have been replaced by safer and more effective agents. When he arrived home his wife gave him a glass of lemonade in which she had dissolved a powder she believed would prevent him from drinking alcohol. vitamins, herbal supplements, etc. Type Small Molecule Groups Experimental Structure Potassium antimony tartrate (tartar emetic), sodium antimony tartrate, the thioxanthone, hycanthone, and the 5-nitrothiazole, niridazole, were formerly used in the treatment of schistosomiasis, but have been largely superseded by less toxic compounds. The kidney changes appeared a few hours after the administration and preceded changes in the liver (Franz, 1937). It is not used to treat S. mansoni or S. haematobium infections because less toxic agents are effective [American Medical Association (AMA) 1977]. Potassium Antimony Tartrate, Trihydrate Safety Data Sheet according to Federal Register / Vol. Before using Antimony Potassium Tartrate, inform your doctor about your current list of medications, over the counter products (e.g. Several antimonials, such as 8-hydroxyquinoline antimony, antipyrin antimony and thiouracil antimony (Table 9.1), among others (Medical Research Committee of Ministry of Health & National Schistosomiasis Research Committee, 1961a,b; National Schistosomiasis Research Committee, 1959; Shiao et al., 1960), showed promising results against S. japonicum in animal studies, and hence these compounds progressed into clinical trials. Potassium antimonyl tartrate sesquihydrate , its cas register number is 28300-74-5. Usually this dose schedule provides high cure rates. She produced a package labeled “tartaro emetico.” Contact with the regional poison center disclosed that the content could be, Manson's Tropical Infectious Diseases (Twenty-third Edition), Carolyn A. Tylenda, ... Bruce A. Fowler, in, Handbook on the Toxicology of Metals (Fourth Edition), Comprehensive Toxicology (Second Edition). Repurposing existing drugs not only accelerates drug discovery but rapidly advances clinical therapeutic strategies. It is hazardous, so the first aid measures and others should be known. Find here Antimony Potassium Tartrate, 28300-74-5 manufacturers, suppliers & exporters in India. mordant - a substance used to treat leather or other materials before dyeing; aids in dyeing process. Harmful if inhaled. The drug therapy of schistosomiasis was first initiated with the use of tartar emetic (Potassium antimony tartarate) in 1918 by the British physician Dr. J.B. Christopherson in Khartoum Civil Hospital, Sudan. Use of antimony potassium tartrate has been abandoned as an emetic to give patients, but it is still used as an emetic to combine with certain rodenticides to make them less harmful if they are accidentally consumed by people or pets. 23 potassium antimony tartrate products are offered for sale by suppliers on Alibaba.com A wide variety of potassium antimony tartrate options are available to you, There are 15 suppliers who sells potassium antimony tartrate on Alibaba.com, mainly located in Asia. Other compounds. It is well tolerated and cause few side effects, mainly nausea, vomiting, malaise, and abdominal pain; most of these symptoms are thought to be caused by immune response to dying worms. … 1-2H 2 O. fluid, and sodium polystyrene sulfonate was administered. In one severe acute oral poisoning, a three-year-old girl drank nearly 50 mL of a sweet tasting liquid against ants containing 2.3 g tartar emetic, several times the lethal dose for children. GHS P Statement IF SWALLOWED: Immediately call a POISON CENTER or … Butanedioic acid, 2,3-dihydroxy- (2R,3R)-, dipotassium salt. In order to achieve reasonably high cure rates 70%, the drug had to be administered daily for up to 20 doses by means of intravenous injection with a total dose of 25 mg/kg. The combination of local infiltration of antimonials with cryotherapy was superior to each treatment alone.97, Antimonials are rather toxic drugs and systemic treatment leads to frequent side-effects such as anorexia, vomiting, nausea, abdominal pain, a metallic taste in the mouth, arthralgia, myalgia, acute pancreatitis especially in HIV-co-infected patients, hepatitis and cardiac arrhythmias. Potassium antimony tartrate is the most potent trivalent antimony compound. 58 / Monday, March 26, 2012 / Rules and Regulations . Persons who died, perhaps as a result of individual susceptibility, following the usual, intravenous, therapeutic dose of tartar emetic showed marked degeneration of the liver, some necrosis of the renal tubular epithelium, and varying degrees of hemorrhage (McKenzie, 1932). dose of tartar emetic by mistake instead of sucrose were chelated with DMSA and survived (Zhang & Ye, 1962). Blanc et al. Antimony potassium tartrate hydrate is a compound used in the treatment of schistosomiasis. Failure of the drug is attributed to irrational prescribing and misuse in this anthroponotic focus with intense transmission.95 In other parts of the world, antimonials continue to be effective. Glucantime is available as a solution containing 85 mg/ml of Sb; it is injected either by intramuscular or intravenous routes. Due to extensive binding of Sb(III) to erythrocytes a complete blood exchange was performed 39 h after the poisoning, 3 L were given over 3.5 h. This late intervention was due to the blood type of the child, A1B rhe pos. She was discharged without internal or neurological adverse symptoms. Nevertheless, short-course antimony therapy became the mainstay of antischistosomal treatment in P.R. It can react with strong oxidizing agents. CAS No. meso-Antimony potassium tartrate. ANTIMONY POTASSIUM TARTRATE reacts with tannic acid, alkalis and their carbonates, lead salts, astringent infusions (cinchona, rhubarb, etc. Potassium antimony tartrate (tartar emetic), sodium antimony tartrate, the thioxanthone, hycanthone, and the 5-nitrothiazole, niridazole, were formerly used in the treatment of schistosomiasis, but have been largely superseded by less toxic compounds. The compound has long been known as a powerful emetic. Finally, not only trivalent but also pentavalent antimonials—interestingly, the drugs of choice against leishmaniasis that are still employed today after decades of use (Blum and Hatz, 2009; Tuon et al., 2008)—were studied for their efficacy against S. japonicum. lumbricoides and Ancyl.duodenale, but not N. americanus. A 34-year-old Central American male presented in the emergency department of Massachusetts General Hospital with diarrhea, vomiting and abdominal pain. We supply our chemical product Levodopa.Purestar Chem Enterprise Co., Ltd. (also known as Huzhou Purestar Biochem Co.,Ltd),is located in Huzhou,150km from Shanghai,we have our own factory in Zhejiang,which covers an area of 3,5000 m2,with complete R&D,manufacture,sales,QC,QA,warehouse departments.And … They are rapidly excreted by the kidneys. Nó là muối kali và antimon của axit tartaric. Wang B, Yu W, Guo J, Jiang X, Lu W, Liu M, Pang X J Pharmacol Exp Ther 2015 Jan;352(1):129-38. The usual dose of tartar emetic is 1-1.5 g/ animal given intravenously, while stibophen may be administered intramuscularly or subcutaneously at a dose of 3-6 g/100 kg. Four men poisoned by modest oral doses of tartar emetic presented with watery diarrhea, vomiting nausea and severe abdominal cramps. Click the link for more information. Potassium antimony(III) tartrate hydrate may be used as a standard during the quantification of Sb species present in the juices by HPLC. It is hazardous, so the first aid measures and others should be known. High purity, submicron and nanopowder forms may be considered. Marsden et al. ), allergies, pre-existing diseases, and current health conditions (e.g. Potassium antimony tartrate is the most potent trivalent antimony compound. Get contact details & address of companies manufacturing and supplying Antimony Potassium Tartrate, 28300-74-5 across India. Antimony potassium tartrate is a schistosomicide possibly useful against other parasites. Potassium Antimony Tartrate is generally immediately available in most volumes. Compared to PAT, Sb-273 showed a better safety profile (i.e. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. including trade names and synonyms. It is used as a mordant in dyeing. Although sodium antimony dimercaptosuccinate and ammonium antimony gluconate showed similar or even higher efficacy than PAT in animal infection, and were somewhat better tolerated by humans, an important shortcoming was that both drugs lacked stability in solution, which hindered their further use in the treatment of schistosomiasis (Chen et al., 1958; Hsu et al., 1960; Medical Research Committee of Ministry of Health & National Schistosomiasis Research Committee, 1960a; National Schistosomiasis Research Committee, 1959). The drug has also been used to treat visceral leishmaniasis and post-kala-azar dermal leishmaniasis [3,10]. BAL chelation continued for 10 days with decreasing doses from 600 mg/day to 200 mg/day. There is increasing concern about the development of resistance to praziquantel, but fortunately it has not been materialized. Mines approved respirator (USCG, 1999). Potassium Antimony Tartrate, … The average blood level in the Japanese study was 0.016 μg/g. Potassium antimonyl tartrate sesquihydrate, 99+% Show More Show Less: Safety and Handling GHS H Statement Toxic to aquatic life with long lasting effects. (e) Urea stibamine (6): Based on the testing of a variety of antimonials, Brahmachari introduced urea stibamine as a clinically useful drug in 1920, which was successfully used in an epidemic of leishmaniasis sweeping the eastern part of India in the early 1920s [22–28]. antimony potassium tartrate synonyms, antimony potassium tartrate pronunciation, antimony potassium tartrate translation, English dictionary definition of antimony potassium tartrate. injections of glucamtine (meglumine antimonite) up to 4 ampoules of 425 mg Sb per day, total 50–52 ampoules over 2 weeks, slightly more than the recommended dose of 20 mg/kg per day for 2 weeks. A dose of 20 mg/kg for 15 days of the drug was equally effective. Adverse effects are associated with therapeutic use and the accidental ingestion of pesticides. Antimony potassium tartrate solid is a colorless crystalline solid or a white powder. This page contains information on the chemical Antimony potassium tartrate including: 41 synonyms/identifiers; U.S. Code of Federal Regulations Title 49 Section 172 shipping regulations and proper shipping name; USDOT 2008 Emergency Response Guidebook initial response information. Thakur [15b] has recently reviewed the current status of the treatment of kala-azar in India. Other drugs like oxmniquine, which is effective against S. mansoni only, was used extensively in Brazil but has now been replaced by praziquantel. Tartar emetic (10) and stibophen (16) have been used to treat Trypanosoma congolense and T. vivax infections in cattle and T. evansi in camel. Antimony potassium tartrate hydrate is used in the treatment of schistosomiasis. Web site owner: Contact with eyes or skin causes irritation. The patient received close monitoring and supportive treatment, i.v. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. Get contact details & address of companies manufacturing and supplying Antimony Potassium Tartrate, 28300-74-5 across India. Potassium sodium tartrate tetrahydrate, also known as Rochelle salt, is a double salt of tartaric acid first prepared (in about 1675) by an apothecary, Pierre Seignette, of La Rochelle, France.Potassium sodium tartrate and monopotassium phosphate were the first materials discovered to exhibit piezoelectricity. 28300-74-5, EC Number 234-293-3. She produced a package labeled “tartaro emetico.” Contact with the regional poison center disclosed that the content could be antimony potassium tartrate, and that the dose he had consumed was in fact potentially lethal. It is not absorbed from the gut, is very bright red in color, and stains the feces red. A dose of 8 mg/kg or 600 mg of SbV +/day/person given for 10 days has been found to cure patients suffering from L. chagasi, L. mexicana spp., L. mexicana amazonensis and other species of the L. mexicana complex . The recommended dosage for systemic antimonial treatment in CL and MCL is 20 and 30 days respectively at 20 mg/kg per day.1,96, Intralesional treatment of meglumine antimoniate is widely used in CL but has only been validated for L. tropica. The introduction of tartar emetic (1) in 1912 for the treatment of mucocutaneous leishmaniasis heralded a new era in the treatment of the disease, which was followed by the investigation of a number of other antimonials for clinical efficacy in leishmaniasis. duodenale and has no useful effect against other intestinal worms. These drugs are toxic and require great care of animals during treatment. Potassium antimonyl tartrate sesquihydrate, its cas register number is 28300-74-5. It has been used for treating a number of tropical diseases, and it still is the drug of choice for treating infection by Schistosoma japonicum. The products differ by the strength of the SbV solution: meglumine antimoniate solution contains 8.1% of Sbv (81 mg SbV/mL) and sodium stibogluconate contains 10% Sbv (100 mg SbV/mL). It is soluble in water. When he arrived home his wife gave him a glass of lemonade in which she had dissolved a powder she believed would prevent him from drinking alcohol. Out of scope information includes radiopharmaceuticals, contrast media, herbals, homeopathics, and food.  found that the drug may be given at a dose of 20 mg/kg daily for 85 days to achieve successful treatment of leishmaniasis. Satyavan Sharma, Nitya Anand, in Pharmacochemistry Library, 1997. It is used in textile and leather processing and as an insecticide. Antimony potassium tartrate Accession Number DB15587 Description. Patients <2 or >45 years with signs of advanced VL and/or severe malnutrition are at higher risk of death during antimonial therapy.22,98 Patients should be closely monitored through serum chemistry, complete blood counts and electrocardiography. Antimony potassium tartrate hydrate is a compound used in the treatment of schistosomiasis. The treatment may be repeated if required . Pentostam is available as a 33% solution (equivalent to 10% SbV +)  or 100 mg SbV +/ml , which should be stored in a refrigerator and administered intramuscularly or intravenously. Presumably the compound is more stable in rodenticide formulations than ipecac, which now is considered a faster and safer emetic for patients. 1-2H 2 O. Fatty degeneration occurred in the convoluted tubules of the kidney and the liver after a single administration of 60 mg antimony potassium tartrate solution to rabbits. DL-Antimony potassium tartrate. tartrate - a salt or ester of tartaric acid. China for several years. followed by oral 100 mg DMPS 3 times per day for 10 days followed by 3 times 50 mg per day for another 10 days. ANTIMONY POTASSIUM TARTRATE reacts with tannic acid, alkalis and their carbonates, lead salts, astringent infusions (cinchona, rhubarb, etc. USA.gov. (b) Sodium stibogluconate (2): The fivevalent form of this drug, pentostam, is the drug of choice for treating different forms of leishmaniasis. Further symptoms of exposure include nervous complaints (i.e., irritability, dizziness, muscular and neurological pain). A major drawback of the procedure is that it is rather painful and causes too much discomfort to be used in small children. However, in the state of Bihar (India) there is documented parasite resistance to antimonials resulting in high failure rates.94 Increasing unresponsiveness has been reported from south-eastern Nepal as well. Antimony potassium tartrate is the most potent and most toxic of the trivalent antimony compounds. 9.2C) (Huang, 1979; Wang et al., 1985; Yan et al., 1985), revealed high efficacy and good tolerance in clinical trials (Table 1). National Ocean Service, Contents. EC Index Number 234-293-3 There is a real concern about their use in treatment of schistosomiasis in areas where malaria is endemic for fear of inducing malaria resistance to artimisinuim derivates. ), acacia, antipyrene and mercury bichloride. (Iffland & Bösche, 1987). The patients received pentostam at a dose of 20 mg SbV +/kg intravenously daily for 28 days after which 77% patients were cured. Parent Compound: CID 875 (Tartaric acid) Component Compounds: CID 5462222 (Potassium) CID 5354495 (Antimony) CID 875 (Tartaric acid) Dates: Modify . Click the link for more information. He had been drinking in the night. Antimony potassium tartrate was once used as an emetic for treating patients poisoned by a wide variety of compounds. National Oceanic and Atmospheric Administration. It is advised to give a full course of pentostam treatment to avoid risk of relapse of visceral leishmaniasis, which eventually leads to post kala-azar dermal leishmaniasis. It may also be used in the preparation of novel Sb(III)-containing polyanions by reacting with trilacunary Keggin-type polyanions. As expected, the efficacy of these abridged antimonial treatment courses was lower compared to the standard 20-day therapy. It also reacts with acids, salts of heavy metals, albumins, soap and tannins. A 70-year-old 60 kg French lady with cutaneous mediterranian leischmaniasis attracted during a holiday in Spain was treated with i.m. Gastric lavage and activated charcoal, rehydration, oxygen by face mask were rapidly instituted, and all 4 patients were chelated with BAL, 200 mg i.m. The rate of recovery fell only very slowly in subsequent days (Boyd and Roy, 1929). pregnancy, upcoming surgery, etc. 77, No. Antimony-Wikipedia Antimony potassium tartrate, also known as potassium antimonyl tartrate, potassium antimontarterate, or emetic tartar,  has the formula K 2 Sb 2 (C 4 H 2 O 6) 2 and is the double salt of potassium and antimony of tartaric acid.The compound has long been known as a powerful emetic, and was used in the treatment of schistosomiasis and leishmaniasis.. George A. Conder, in Antibiotic and Chemotherapy (Ninth Edition), 2010. Antimony potassium tartrate is a schistosomicide possibly useful against other parasites. fluid, and sodium polystyrene sulfonate was administered. It is soluble in water. In Brazil an adult dose of 17-28 mg/kg administered intramuscularly daily for 10-20 days is recommended for patients suffering from cutaneous and mucocutaneous leishmaniasis caused by L. braziliensis braziliensis [8,13b,18,19]. Prolongation of a corrected Q-T interval (>0.5 s) in an electrocardiogram is an ominous sign and can culminate into ventricular arrhythmias and death. The small safety factor is indicated by the fact that in one case a dose of 130 mg proved fatal (Osol et al., 1967). It is used in making insecticides or pesticides. CAS # EC Number Hill Formula Chemical Formula Molar Mass 28300-74-5 234-293-3 C₈H₄K₂O₁₂Sb₂ * 3 H₂O K₂(SbO)₂C₈H₄O₁₀ * 3 H₂O 667.89 SAFETY DATA SHEET: ANTIMONY POTASSIUM TARTRATE ANTIMONY POTASSIUM TARTRATE A816.10 INTEGRA Chemical Company 24 Hour Emergency Response: CHEMTREC 800-424-9300 (Outside USA 703-527-3887) 1216 6th Ave N Kent WA 98032 Phone: 253-479-7000 Tartar emetic is produced when potassium tartrate is heated with antimony trioxide. Potassium Antimony Tartrate Solution Safety Data Sheet according to Federal Register / Vol. Office of Response and Restoration, & indicates that no RQ is assigned to this generic or broad class, although the class is a CERCLA hazardous substance. Antimony potassium tartrate Accession Number DB15587 Description. Antimony potassium tartrate solid is a colorless crystalline solid or a white powder. DMPS is an option for treatment of systemic intoxications with metals including antimony. In Sudan it costs 40 US cents per tablet, this is mainly due to new manufacturers in Korea, China, Egypt, Sudan, Brazil, and other countries. Bephenium, a quaternary ammonium compound formulated as the hydroxynaphthoate, is effective against several nematodes, including Asc. Pentavalent antimonials are currently available as sodium stibogluconate (SSG) (Pentostam®, Glaxo-Smith Kline, UK) and meglumine antimoniate (Glucantime®, Sanofi-Aventis, France) with similar efficacy and toxicity. 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